Description :

Innovative interventions to prevent the harmful effects of using digital technologies on the mental health of children and young adults - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-DISEASE-02).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• Researchers and healthcare professionals have an improved understanding of the neuro-biological and cognitive/behavioural evidence base on the correlation and impact of digital technologies on mental health, including brain development.
• Policymakers and digital technology and content developers are provided with a robust evidence base on the impact (positive or negative) of digital technologies on mental health in children and young adults[1].
• Policymakers, digital technology developers, and educational institutions amongst others make use (e.g. developing guidelines) of the evidence base and widely implement the newly developed interventions aimed at promoting children and young adults’ mental health while mitigating any negative impacts of digital technology use.
• Children, young adults, families, guardians, educators, and carers have access to the newly developed interventions designed to prevent harm and promote the positive use of digital technologies.
• Children and young adults are empowered and develop resilience, including digital literacy, enabling them to engage in a healthy and positive way with digital technologies.
   

Description :

Towards climate resilient, prepared and carbon neutral populations and healthcare systems - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-ENVHLTH-04).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Living and working in a health-promoting environment”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to most of the following expected outcomes:

• The healthcare sector is supported with new technological developments and frameworks for greening, decarbonising and adapting to climate change, thus also contributing to protect biodiversity and ecosystem services.
• Governments, public health authorities, healthcare providers and practitioners, social care services and civil society have access to the best available evidence on the health costs and benefits (including co-benefits) of climate adaptation and mitigation actions and interventions.
• Policymakers and public authorities develop environment, climate change and health policies and interventions based on robust frameworks and incorporating innovative, inclusive and accessible solutions and technologies.
• Governments and public health authorities are supported in their adoption of robust frameworks and interventions to tackle societal challenges linked to the health impacts of climatic and environmental factors.
• Populations are empowered and equipped with knowledge, tools and resources to adopt health-protective behaviours and adapt to health-related climate risks.

Description :

Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-TOOL-03).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Developing and using new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to several of the following expected outcomes:

• Researchers are in possession of improved human-relevant New Approach Methodologies (NAMs) platforms that capture the genetic, phenotypic, age-related, immune, microbiome, and environmental exposure variability of the human population.
• These innovations support more equitable healthcare solutions and personalised treatment strategies across diverse life stages.
• Industry gets access to platforms that allow a faster pace of innovation for the development of more cost-effective targeted therapeutic interventions and improvement of the safety assessment of chemicals, other medicinal products, and medical devices.
• Patients benefit from innovative platforms and strategies that improve prediction, prevention and treatment of diseases, in particular through enhanced understanding of disease pathways and mechanisms.
• The general population is better protected through a safer environment, as these platforms enhance the detection and mitigation of risks posed by chemicals and other potentially harmful substances.
• Regulatory bodies gain confidence and trust in NAMs, supporting their integration into product development, risk assessment, and approval processes.
• Fewer live animals are used in biomedical research and regulatory testing.

Description :

Development of novel vaccines for viral pathogens with epidemic potential - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-DISEASE-04). 

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• The scientific and clinical communities have a better understanding of and access to experimental vaccines for the prevention and treatment of emerging or re-emerging viral infections, as well as for further clinical investigation, including better understanding of biological sex and social determinants that influence immune response, vaccine efficacy, safety, and uptake.
• Candidate vaccines are available for emerging and re-emerging viral infections, increasing therapeutic options for clinical deployment in case of an epidemic or pandemic.

Description :

Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-DISEASE-11)

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• Researchers, developers of medical interventions, and healthcare professionals have a better understanding of biological sex and/or gender-specific health determinants, risk factors and pathways for cardiovascular diseases.
• Researchers, developers of medical interventions, and healthcare professionals have access and use sex and/or gender-specific or tailored risk models for better prevention, detection and diagnostic and treatment strategies.
• Healthcare systems benefit from novel sex and/or gender-specific strategies for prevention, detection, diagnosis and treatment options, resulting in reduced burden of cardiovascular diseases.

Description :

Multisectoral approach to tackle chronic non-communicable diseases: implementation research maximising collaboration and coordination with sectors and in settings beyond the healthcare system (GACD) - Cluster 1 - Health (Single stage - 2026) HORIZON-HLTH-2026-01-DISEASE-09).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to some of the following expected outcomes:

• Researchers, policymakers, healthcare- and non-healthcare-related stakeholders and authorities in low- and middle-income countries (LMICs)[1] and/or those in high-income countries (HICs) serving disadvantaged populations have access to improved insights and evidence on how to maximise collaboration and coordination with sectors and in settings beyond the healthcare system in the context of Non-Communicable Diseases (NCDs).
• Researchers, policymakers, healthcare- and non-healthcare-related stakeholders and authorities have an improved understanding how the proposed interventions draw on collaborative multisectoral engagement and utilise the different settings in which people are educated, work and live, to expand efforts to reduce risks, prevent, manage and control NCDs.
• Communities, relevant stakeholders from different sectors and authorities are fully engaged in implementing and taking up interventions that tackle the growing burden of NCDs through actions in sectors and settings outside the traditional health system and its facilities health-related outcomes, improve quality of life across the life course and extend healthy life expectancy.

Description :

Biological, social and environmental factors that impact the trajectory of brain health across the lifespan – in the field of neurodegeneration (EP BrainHealth Call 2).

Maintaining brain health and facing the burden caused by brain disorders, including neurological, neurodegenerative and mental diseases alike, are paramount for all societies in Europe and beyond.

Brain disorders are a leading cause of disability and mortality globally, placing a great burden on people living with brain disorders, their families, social relations, professional and informal carers, as well as healthcare systems and national economies as a whole. In 2021, an estimated 3.4 billion individuals had a condition affecting the nervous system, corresponding to around 43% of the world’s population. This also creates enormous financial pressure on healthcare systems and economies, as the total cost of neurological diseases is estimated at around 1.7 trillion and the economic burden of mental disorders to over 600 billion Euro in Europe per year.

Furthermore, the current geopolitical and environmental crises as well as increasing economic pressure in many countries worldwide have further aggravated brain health problems, in particular for the most vulnerable.

Timeline

• 8th of December 2025    Pre-Announcement
• 8th of January 2026    Launch
• 10th of March 2026    Pre-proposal deadline 14:00 CET
• End of May 2026    Formal invitation to submit a full proposal
• 30th of June, 2026    Submission deadline of full proposals 14:00 CEST
• September, 2026    Peer Review Panel meeting to assess the full proposals
• November 2026    Final funding decision by the CSC and start of national administrative procedures
• Early – Mid 2027    Start of funding

Description :

Biological, social and environmental factors that impact the trajectory of brain health across the lifespan – in the field of neurological, mental and sensory disorders (EP BrainHealth Call 1).

Maintaining brain health and facing the burden caused by brain disorders, including neurological, neurodegenerative and mental diseases alike, are paramount for all societies in Europe and beyond.

Brain disorders are a leading cause of disability and mortality globally, placing a great burden on people living with brain disorders, their families, social relations, professional and informal carers, as well as healthcare systems and national economies as a whole. In 2021, an estimated 3.4 billion individuals had a condition affecting the nervous system, corresponding to around 43% of the world’s population. This also creates enormous financial pressure on healthcare systems and economies, as the total cost of neurological diseases is estimated at around 1.7 trillion and the economic burden of mental disorders to over 600 billion Euro in Europe per year.

Timeline

• 8th of December 2025    Pre-Announcement
• 8th of January 2026    Launch
• 10th of March 2026    Pre-proposal deadline 14:00 CET
• End of May 2026    Formal invitation to submit a full proposal
• 30th of June, 2026    Submission deadline of full proposals 14:00 CEST
• September, 2026    Peer Review Panel meeting to assess the full proposals
• November 2026    Final funding decision by the CSC and start of national administrative procedures
• Early – Mid 2027    Start of funding

Description :

IHI call 12 is a single-stage, applicant-driven call with topics aligned with the specific objectives of the IHI Strategic Research and Innovation Agenda.

Topics
The call contains five topics, each focusing on one of the five IHI Specific Objectives (SOs) as set out in the Strategic Research and Innovation Agenda (SRIA):

• Topic 1 (SO1): Boosting innovation for a better understanding of the determinants of health
• Topic 2 (SO2): Boosting innovation through better integration of fragmented health R&I effort
• Topic 3 (SO3): Boosting innovation for people-centred integrated healthcare solutions
• Topic 4 (SO4): Boosting innovation through exploitation of digitalisation and data exchange in healthcare
• Topic 5 (SO5): Boosting innovation for better assessment of the added value of innovative integrated healthcare solutions

For full details of the topics, including the budget breakdown, read the call text. All documents relating to the call can be found via the Funding and Tenders Portal and the IHI call documents page. We advise you to read these documents, in particular the guide for applicants, carefully.

Important information on eligibility for funding
Applicants should note that legal entities based in the following countries are not eligible to receive funding for some of the topics in this call.

Key dates and deadlines

• Call outline announced: 23 September 2025. Draft topic texts published: 14 October 2025, updated 18 November 2025. Approved topics published: 11 December 2025.
• Call launch: 15 January 2026
• Full proposal submission deadline: 21 April 2026 at 17:00 Brussels time

Other useful information
Call ID: HORIZON-JU-IHI-2026-12-SINGLE-STAGE | Action type: RIA - Research and Innovation Actions | Call type: Single-stage