Description :

Innovative healthcare interventions for non-communicable diseases - Cluster 1 - Health (Two stage - 2027) (HORIZON-HLTH-2027-02-two-stage).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• Researchers, developers and clinical practitioners have access to state-of-the-art knowledge, data, technologies, tools, methods, best practices, and trainings to develop innovative healthcare interventions aimed at reducing burden of the following specific Non-Communicable Diseases (NCDs): cardiovascular diseases, diabetes, chronic respiratory diseases or chronic kidney diseases.
• Scientific and clinical communities can use innovative healthcare interventions to generate meaningful advances in clinical practice and care for patients with NCDs following validation in late-stage clinical trials.
• Scientific and clinical communities make wide use of relevant databases and/or integrate them with existing infrastructures for storage and sharing of collected data according to FAIR[1] principles, thereby encouraging further use of the data.
• Policymakers, scientific and clinical communities, developers, patient organisations, regulators, and other relevant bodies are informed of the research advances made and the requirements for a widespread implementation of the innovative therapeutic interventions and complementary approaches.
• Patients and caregivers are constructively engaged with the research, ensuring that their needs are catered for, with the aim of tangibly benefitting from the interventions.

Description :

Boosting mental health of young cancer survivors through the European Cancer Patient Digital Centre (ECPDC) - Supporting the implementation of the Cancer Mission (HORIZON-MISS-2026-02-CANCER-05).

Expected Outcome:
Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to the following expected outcomes:

• Through the European Cancer Patient Digital Centre (ECPDC), adolescent and young cancer patients and survivors as well as their caregivers have access to innovative tools and approaches to strengthen their mental health.
• Healthcare professionals have access to innovative tools to monitor and support the mental health of cancer patients and survivors as well as their caregivers.
• Researchers and healthcare professionals have access and use reliable patient reported data to better understand the mental health needs of cancer patients and survivors and provide effective care.

Description :

Pragmatic clinical trials to optimise immunotherapeutic interventions for patients with refractory cancers - Supporting the implementation of the Cancer Mission (HORIZON-MISS-2026-02-CANCER-03).

Expected Outcome:
Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:

• Patients with refractory cancers and their caregivers/families will have access to optimised, tailored and affordable immunotherapeutic interventions that increase their quality of life, across European regions, EU Member States and Associated Countries;
• Healthcare professionals and academia will have access to clinical evidence, on effectiveness of immunotherapeutic interventions, to deploy evidence-based treatment interventions with improved patient selection that improve outcomes in real life, i.e. in routine healthcare, for patients with refractory cancers who often present with co-morbidities;
• National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated Countries will have the evidence to implement and reimburse optimised and affordable immunotherapeutic interventions in their healthcare systems, including in everyday medical practice.

Description :

Virtual Human Twin (VHT) Models for Cancer Research - Supporting the implementation of the Cancer Mission (HORIZON-MISS-2026-02-CANCER-01).

Expected Outcome:
Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:

• Researchers of different disciplines use advanced multiscale Virtual Human Twins (VHTs) to expand the knowledge and understanding of cancer onset and progression
• Healthcare professionals and researchers have access to advanced VHT-based solutions that model cancer onset and progression over time, contributing to improve personalised treatments
• Researchers, healthcare professionals, innovators and citizens have access to cancer VHTs through the UNCAN.eu and the advanced Virtual Human Twin platforms

Description :

Supporting the implementation of the Cancer Mission (HORIZON-MISS-2026-02-CANCER-07)

Expected Outcome:
Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to the following expected outcomes:

• Improved understanding of care needs of older patients with cancer and approaches to address them.
  Older cancer patients gain access to innovative age-specific approaches and tools better tailored to their care needs.
• National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated
• Countries have the evidence to implement tailored care for older cancer patients that have the potential to be implemented in routine treatment and follow-up care in their healthcare systems.

Description :

Towards a better understanding and anticipation of the impacts of climate change on health - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-ENVHLTH-01).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Living and working in a health-promoting environment”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to most of the following expected outcomes:

• Citizens, patients, public authorities, social care services, healthcare practitioners and policymakers have a better understanding of the climatic health risks and determinants of disease and are better equipped to address health outcomes through enhanced and inclusive prevention, resilience, adaptation, preparedness and response, including better diagnosis and treatment.
• Governments, public health authorities, researchers and civil society organisations are supported to tackle societal challenges linked to the health impacts of climatic factors.
• Public authorities, organisations and the research community can rely on data collection and sharing according to FAIR[1] principles and leveraging of data availability and quality.
• Policymakers and public authorities develop evidence-based climate change and health policies and interventions that are nature positive, inclusive and responsive to diverse population needs.

Description :

Identifying and addressing low-value care in health and care systems - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-CARE-03).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Ensuring equal access to innovative, sustainable, and high-quality healthcare”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• Healthcare providers and policymakers make use of evidence-based indicators and methodologies to identify low-value care[1] practices, as well as opportunities for improvement and tools to monitor such improvements.
• Healthcare professionals are equipped with the knowledge and tools to implement guidelines for reducing or discontinuing low-value care activities and maintaining effective and patient-centred practices that ensure quality of care.
• Patients and citizens benefit from more effective healthcare, by understanding and endorsing measures that reduce low-value care, recognising the potential to achieve higher-quality healthcare and better health outcomes overall.
• Health and care systems benefit from a reduction of low-value care practices, which enables enhanced patient safety and quality of care, while contributing to their efficiency as well as fiscal and environmental sustainability.
• Healthcare organisations can, by identifying low-value care practices, reallocate valuable healthcare resources to other areas of need.

Description :

Pilot actions for follow-on funding: Leveraging EU-funded collaborative research in regenerative medicine - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-TOOL-05).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Developing and using new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• The overall competitiveness of the EU biotechnology sector is strengthened through the further development of closer-to-deployment health innovations.
• The EU benefits from greater impact of the EU’s Research and Innovation (R&I) Framework Programmes through successful leveraging of previous EU funding in the field of regenerative medicine.
• EU innovators secure further funding to finalise the last stages of development.
• Patients benefit faster from solutions that improve their health and wellbeing.

Description :

Regulatory science to support translational development of patient-centred health technologies - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-IND-03).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Maintaining an innovative, sustainable, and competitive EU health industry”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to several of the following expected outcomes:

• Policymakers and regulators will get accelerated access to improved evidence driven methodologies to evaluate the impact and efficiency of novel health technologies, facilitating decision-making for their use in humans and uptake in clinical practice.
• Patients and the health systems will benefit from the more targeted and efficient uptake of safe and effective health innovations in clinical practice, supporting more personalised approaches and improved care and public health.

Description :

Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions - Cluster 1 - Health (Single stage - 2026) (HORIZON-HLTH-2026-01-DISEASE-03).

Expected Outcome:
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:

• All players along the healthcare value chain have access to evidence-based treatment and management strategies for post-infection conditions and improve patient recovery and quality of life across diverse populations.
• Public health authorities and healthcare practitioners have access to effective prevention, diagnostic and treatment tools, ensuring better allocation of healthcare resources.
• Healthcare systems improve their efficiency and reduce long-term economic burdens by streamlining post-infectious disease care and addressing disparities in healthcare access.
• Public health authorities have access to evidence-based information to integrate research findings into policy for improved public health preparedness and resilience, including training of healthcare staff and enhanced long-term disease management guidelines.