PEARLDIVER

EU-PEARLDIVER is a multinational European platform trial for depression to rapidly and robustly assess the efficacy and safety of several therapies simultaneously. With this innovative trial design, new treatments can be added over time as they become available and treatments that turn out to be ineffective will be dropped.

The trial is designed to accommodate different types of drugs and may also include non-pharmacological treatments such as psychotherapy or non-invasive neuromodulation in the future. In a platform trial, several experimental treatments share a control group, which can help to make it faster, more efficient, and more patient-centric.

Population: Adults (18-70 years) with a treatments-resistant major depressive disorder | Intervention type: Interventional clinical trial under the EU Clinical Trials Regulation (CTR), using a platform trial design